O2 and O3 treatments

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Over several decades, prestigious journals have published in vitro studies on the capacity of ozone to induce direct damage on tumor cells and, as well, to enhance the effects of radiotherapy and chemotherapy. Indirect effects have been demonstrated in animal models: immune modulation by ozone alone and sensitizing effect of radiotherapy by concurrent ozone administration. The effects of ozone in modifying hemoglobin dissociation curve, 2,3-diphosphoglycerate levels, locoregional blood flow, and tumor hypoxia provide additional support for potential beneficial effects during cancer treatment. Unfortunately, only a few clinical studies are available. Finally, we describe some works and our experience supporting the potential role of local ozone therapy in treating delayed healing after tumor resection, to avoid delays in commencing radiotherapy and chemotherapy.

Ozone therapy and cerebral blood flow assessed by SPECT-ECD. Cerebral blood flow assessed by single photon emission computed tomography (SPECT) with ECD (99mTc-ethyl cysteinate dimer); the tracer correlates with cerebral blood flow. The figure depicts a 68-year-old patient with a left parietooccipital glioblastoma (astrocytoma Grade IV) following subtotal resection. SPECT with ECD was carried out before (Left) and after 3 O3T sessions on alternate days (Right). After 3 sessions of O3T, (1) overall SPECT-index in brain increased from 60% to 90% and (2) in the tumor area (section #11) SPECT-index increased from 28% to 49%, increase >50%. Note that there are different scales before and after O3T.


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