Alternative Cancer Care

What do we know?

No conjecture. No fear mongering. Just the scientific facts.

Cancer is a state that leaves the body deficient in vitamin C—a state of metabolic scurvy if you will.

Many claim that the evidence on vitamin C is sparse, incomplete, inconclusive, or is ineffective or worse, detrimental to the conventional triad of surgery, chemotherapy, and radiation.

An analysis of the large volume of literature present on vitamin C in the prevention, but more specifically, the treatment of cancer, just does not support any of those conclusions. In fact, the evidence points to the overwhelming conclusion that vitamin C, particularly intravenous vitamin C, should be a part of every treatment plan in people with cancer and in individuals with other illnesses, i.e., viral infections and bacterial infections.

Here is what the science says about vitamin C and cancer.

Intravenous vitamin C is effective against a wide variety of cancer types including the following: 1, 2, 3, 4

• Brain (glioblastoma) cancer
• Ovarian cancer
• Lung cancer
• Leukemia
• Hodgkin’s lymphoma
• Non-Hodgkin’s lymphoma
• Pancreatic cancer
• Breast cancer
• Melanoma
• Gastric cancer
• Liver cancer
• Colorectal cancer
• Bladder
• Neuroblastoma
• Multiple Myeloma
• Sarcoma
• Thyroid cancer
• Renal Cell cancer

Vitamin C’s effects against cancer are not limited to just these cancer types; these are just the cancer types that very solid evidence exists to support vitamin C’s use.

Vitamin C is effective in the treatment of any tumor type, listed above or not listed, that preferentially uses glucose via the altered aerobic glycolysis (Warburg effect 5)

The large volume of evidence-based study types that are available on vitamin C in the treatment of cancer includes:

• Case reports and case series
• In vitro studies
• In vivo studies
• Animal research
• Cohort trials
• Randomized controlled trials
• Systematic reviews
• Large Meta-analysis studies

Phase I, II, and III human clinical trials

These study types are exhaustive and are the backbone of the scientific and medical communities—or at least they should be. These are the foundations upon which the medical community builds opinion. This doesn’t include just a few studies but includes 100s and 100s of studies in the U.S. and from around the world. Research is research, whether it is done in the U.S., Germany, Italy or Japan. Study design and bias don’t show a country's preference; just as many biased studies come out of the U.S. as any other country.

What is the best way to take vitamin C for the treatment of cancer? This is not even open for debate—intravenous (IV).

More so, the IV dose should be high-dose. The dose of 25-50 grams per IV simply will not suffice for the treatment of advanced cancer.

With advanced, active cancer, the tumor burden is simply too great to be effective in any positive way via a trickle of vitamin C.

Also, the oral dosing of vitamin C for cancer, including liposomal forms, will simply not work in the treatment of active cancer either. This argument falls flat on its face—the face of pharmacokinetics that is. This is not a new lesson either, but a lesson from history that has been forgotten.

This lesson was learned many years ago from the different outcomes of the studies done by Ewan Cameron and Linus Pauling, which are called the Mayo studies. In 1976,

Ewan Cameron and Linus Pauling (Linus Pauling is considered the father of vitamin C) published 6 their experience with high-dose (10 grams) IV vitamin C in 100 patients with “terminal” cancer. They found a significant 4.2 times prolongation (50 to 210 days) of survival with 10 days consecutive IV vitamin C followed by oral vitamin C compared to untreated individuals. They repeated their study 7 of terminal cancer patients in 1978 to find an improvement in survival above that of their previous study. They found an average increase of survival benefit of 300 days in the IV vitamin C group compared to those untreated. In this second study, 1 year survival was 22% in the IV vitamin C treated group compared to 0.4% in the untreated group. In contrast, there are what are called the Mayo studies. In the first study of 150 patients by ET Creagan et al. 8, at the Mayo Clinic, advanced cancer repeated the study performed by Cameron and Pauling but only used oral vitamin C 10 grams instead of any IV. Their results found no benefit in survival. The same flawed study, which involved oral vitamin C (10 grams) without IV vitamin C and had the same negative survival benefit, was repeated in 1985 by Moertel CG et al.

9. Why the difference? Pharmacokinetics! This difference in the delivery methods of vitamin C by mouth versus intravenous administration provided different pharmacokinetics which led to different results. This should come as no surprise to anyone. Pharmacokinetics is defined as the study of the time movement of a drug through drug absorption, distribution, metabolism, and excretion. From a practical standpoint, pharmacokinetics is how the delivery of a drug, a vitamin, or a mineral is affected by administration through elimination from the body.

Oral vitamin C uptake is regulated by the SVCT1 receptor 10 in the gut lining. There are other receptors, SVCT1 and GLUT1 receptors, but they are not involved with gut absorption of vitamin C, at least as far as we know currently. In the gut epithelial lining, SVCT receptors down-regulate receptor expression with higher encountered vitamin C levels. Thus, the more frequent the dose and the higher the dose of vitamin C, the lower the capacity to uptake vitamin C through the gut.

In contrast, IV vitamin C bypasses this down regulation counter mechanism in the GI epithelial lining. By definition, IV vitamin C is 100% bioavailable.

Vitamin C has been shown to be widely effective in the treatment of specific processes involved in cancer initiation, cancer growth, and cancer spread to include 11, 12, 13, 14, 15, 16

• Directly cell destructive (cytotoxic) to cancer cells
• Stops growth (proliferation) of cancer cells
• Reduces inflammation that propagates cancer
• Provides anti-oxidative support
• Provides pro-oxidative effects that kill cancer cells
• Stimulates the immune system to fight cancer
• Blocks lymphatic (lymphagenesis) recruitment to cancer that promotes systemic spread
• Blocks blood vessel (angiogenesis) recruitment to cancer that promotes systemic spread
• Blocks metastatic spread of cancer
• Changes in genetic expression (epigenetics) that inhibit cancer
• Is anti-viral
• Preserves mitochondrial function

And that is just a small sampling of the evidence that is available that supports the use of IV vitamin C, particularly high-dose, in the treatment of cancer.

If you or someone you love has been diagnosed with cancer, call the EHC Integrative OOncology Cancer Care Center today to learn about how you can begin your healing journey today.

Were you or a loved one recently diagnosed with cancer? We want to help! We are An integrative healing center that specializes in alternative cancer treatment utilizing intravenous treatments that target cancer and enhance the immune system.

Footnotes:

[1] Mata, Ana Maria Oliveira Ferreira da, Carvalho, Ricardo Melo de, Alencar, Marcus Vinícius Oliveira Barros de, Cavalcante, Ana Amélia de Carvalho Melo, & Silva, Benedito Borges da. (2016). Ascorbic acid in the prevention and treatment of cancer. Revista da Associação Médica Brasileira, 62(7), 680-686. https://doi.org/10.1590/1806-9282.62.07.680

2 Lv, H., Wang, C., Fang, T., Li, T., Lv, G., Han, Q., Yang, W., & Wang, H. (2018). Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2. NPJ precision oncology, 2(1), 1. https://doi.org/10.1038/s41698-017-0044-8

3 Su, X., Shen, Z., Yang, Q., Sui, F., Pu, J., Ma, J., Ma, S., Yao, D., Ji, M., Hou, P.. Vitamin C kills thyroid cancer cells through ROS-dependent inhibition of MAPK/ERK and PI3K/AKT pathways via distinct mechanisms. Theranostics 2019; 9(15):4461-4473. doi:10.7150/thno.35219. Available from http://www.thno.org/v09p4461.htm

4 Drisko, J. A., Serrano, O. K., Spruce, L. R., Chen, Q., & Levine, M. (2018). Treatment of pancreatic cancer with intravenous vitamin C: a case report. Anti-cancer drugs, 29(4), 373–379. https://doi.org/10.1097/CAD.0000000000000603

5 Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009). Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (New York, N.Y.), 324(5930), 1029–1033. https://doi.org/10.1126/science.1160809

6 Cameron E, Pauling L. Supplemental Ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal human cancer. (1976). Proc. Natl Acad. Sci. 73(10):3685-3689.

7 Cameron, E., & Pauling, L. (1978). Supplemental ascorbate in the supportive treatment of cancer: reevaluation of prolongation of survival times in terminal human cancer. Proceedings of the National Academy of Sciences of the United States of America, 75(9), 4538–4542. https://doi.org/10.1073/pnas.75.9.4538

8 Creagan ET et al. Failure of High-Dose vitamin C (Ascorbic Acid) Therapy to Benefit Patients with Advanced Cancer—A controlled trial. (1979). N Engl J Med; 301:687-690.DOI:10.1056/NEJM197909273011303

9 Moertel CG et al. High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. (1985). N Engl J Med; 312:137-141.

10 Mandl, J., Szarka, A., & Bánhegyi, G. (2009). Vitamin C: update on physiology and pharmacology. British journal of pharmacology, 157(7), 1097–1110. https://doi.org/10.1111/j.1476-5381.2009.00282.x

11 Manstrangelo, D., Pelosi, E., Castelli, G., Lo-Coco, F., Testa, U., Mechanisms of anti-cancer effects of ascorbate: Cytotoxic activity and epigenetic modulation. (2018). Blood Cells Mol Dis. Mar;69:57-64. doi: 10.1016/j.bcmd.2017.09.005. Epub

12 Abel Ang, Juliet M. Pullar, Margaret J. Currie, Margreet C.M. Vissers. Vitamin C and immune cell function in inflammation and cancer. (2018). Biochem Soc Trans;46(5):1147–1159. doi: https://doi.org/10.1042/BST20180169

13 Zeng, L. H., Wang, Q. M., Feng, L. Y., Ke, Y. D., Xu, Q. Z., Wei, A. Y., Zhang, C., & Ying, R. B. (2019). High-dose vitamin C suppresses the invasion and metastasis of breast cancer cells via inhibiting epithelial-mesenchymal transition. OncoTargets and therapy, 12, 7405–7413. https://doi.org/10.2147/OTT.S222702

14 Vissers, M., & Das, A. B. (2018). Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence. Frontiers in physiology, 9, 809. https://doi.org/10.3389/fphys.2018.00809

15 Bakalova, R., Zhelev, Z., Miller, T., Aoki, I., and Higashi, T. (2020). Vitamin C versus Cancer: Ascorbic Acid Radical and Impairment of Mitochondrial Respiration? Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2020/1504048

16 Pawlowska,E., Szczepanska, J., and Blasiak, J. (2019). Pro- and Antioxidant Effects of Vitamin C in Cancer in correspondence to Its Dietary and Pharmacological Concentrations. Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2019/7286737

Ozone Therapy has tremendous health benefits for the body.

Ozone (oxygen with an extra molecule – O2 + O)

Exercise in a bottle; This increases the blood oxygen levels throughout the entire body.

This treatment stimulates cytokine and interleukin production by the immune system.

Ozone is three atoms of oxygen (O3) while oxygen is two atoms of oxygen (O2). The atmosphere enveloping the surface of the earth is approximately 21% Oxygen, 79% Nitrogen, and very small concentrations of other gases like CO2 and some of what are referred to as noble gasses, like helium and argon.

Pollutants, like S02, NO2 and CO contaminate the atmosphere in volumes which exceed 2000 X 10 to the sixth tons.

When the ultraviolet light of the sun penetrates oxygen (O2) at a certain angle, the two atoms are split and become “singlet oxygen”, which are highly reactive and quickly attach themselves to a stable O2 to become an O3. The O3 is also quite unstable and so, two O2 molecules become three O2 molecules.

The time that the O3 exists before it becomes O2 is extremely brief but it is happening at such an incredibly high rate in such high volumes that there is an ozone layer in the lower part of the stratosphere, about 15 or so kilometers above the earth. This ozone layer deflects much of the harmful UVB light and life would not be possible without ozone in the atmosphere.

Ozone Therapy Benefits Against Cancer

Ozone was discovered in 1840 and used medically by the end of the 19th century. Medical uses of ozone became fairly common in the early 20th century and it predated the advent of the FDA so it is “grandfathered” in as acceptable.

When ozone is mixed with an equal amount of blood and it is gently swirled, the ozone is converted into oxygen, so that the blood has a concentration of around 33% more oxygen than normal, which is not possible by even exercising while wearing an oxygen mask.

Also, the white blood cells produce cytokines and interleukins in response to ozone.

These are immune modulating substances that enhance the entire immune system.

So, when the blood is given back to the person, they are highly oxygenated and their immune systems become supercharged.

For these reasons, medical ozone specifically works to produce an oxygen-rich environment, in which cancer cannot survive.

It also stimulates the recruitment of more cytotoxic lymphocytes to eliminate cancer and other chronic conditions, like microbial infections and other causes of chronic inflammation.

Minor Autohemotherapy

People diagnosed with cancer have cancer cells circulating in their blood.

The goal with Minor Autohemotherapy is to develop a fast response by the immune system by enhancing its capability and functionality.

To create this fast response we withdraw 10 cc’s of blood then add 10 cc’s of ozone to the syringe containing the blood. Then the syringe is shaken briskly. This produces the end result we are looking for as the cancer cells are broken into a multitude of minuscule pieces.

An injection into your muscle is then administered with the contents of the syringe. It will feel the same as any other shot given, nothing different. An inflammatory response is produced by the body as a result of the intramuscular injection.

What this means is the macrophages and other immune cells or white blood cells encase these minuscule pieces and create an immune response. However, this is completely different as there are several hundred minuscule pieces, not what is normally just the outside of the cancer cell.

Ultimately, what the immune system produces is several hundred various types of antibodies and excrete immune boosting interleukins and cytokines on top of what it normally produces with the whole cell on its own. This boosts the immune system’s ability to eliminate cancer tremendously. This is administered three times a week.

Phosphatidylcholine is a phospholipid, a natural agent that is found in mustard, eggs, and sunflower seeds that helps in rebuilding cells.

This is a way of slowing down the aging-related processes, improves brain functioning and memory capacity, strengthens and stabilizes cellular membranes which are crucial for cell signaling and energy transfer.

When phosphatidylcholine is used intravenously it helps in treating atherosclerosis, high cholesterol, liver disease, hepatitis C and fatty tumors.

Combining phosphatidylcholine and curcumin is incredibly toxic to the cells of breast cancer and five times more efficient than using curcumin on its own.

Insulin Potentiation Therapy Or IPT Low Dose Chemotherapy

IPT low dose chemotherapy is a kinder, gentler cancer chemotherapy treatment option with significantly fewer side effects.

FACT: More than 50% of people who receive conventional chemotherapy will die from the side effects of the chemotherapy, NOT from cancer itself.

All cells, including cancer cells, need fuel (glucose) to “burn” in order to produce the energy necessary for survival. Insulin molecules act like keys, which open the glucose doorways allowing the glucose to enter the cells. If there is no insulin around, glucose just keeps circulating in the blood and cannot get into the cells. This is the problem that people with Type 1 Diabetes have. Keep in mind that all keys need a lock to turn in, in order to work. The “locks” on the surface of cells are called insulin receptors.

Cancer cells have developed a very simple and quite effective strategy to assure that they get enough fuel in order to survive. They grow many extra insulin receptors on their surfaces in order to attract and utilize more of the circulating glucose (fuel) than the other non-cancerous cells in the body.

One of the major distinctions between cancer cells and normal cells is that cancer cells have lost the ability to use oxygen when they are “burning” glucose to produce energy. They must resort to a very primitive and inefficient, default method of energy production called, glycolysis or fermentation, much like yeast, certain bacteria, and other primitive organisms. As a result, they need, at least, 19 times more glucose than normal cells just to survive.

So whether one eats a banana, pasta, bread or a candy bar, the cancer is fed first and the rest of the cells get the leftovers.

At EHC BUFFALO0Integrative Oncology Cancer care clinic , we use this knowledge to target the cancer cells with cytotoxic (cell-killing) agents (chemotherapy drugs).

By administering small amounts of insulin prior to the person eating that day, we are able to select the cancer cells from amongst all the other cells in the body because they are able to bind the insulin much more quickly, resulting in what is known as the “therapeutic window” (cancer cells are permeable while the other, normal cells are still hard and impermeable).

There are a multitude of effects upon cells when insulin binds to them and one of these effects is that the cells become more permeable (creating openings) by stimulating an enzyme known as delta-9 desaturase.

Once the cancer cells have been targeted by the insulin to open their doors, we then administer small amounts of the appropriate chemotherapeutic drugs, from 5% to 10% of the standard dose.

Much of what we administer becomes absorbed into the cancer cells rather quickly and not into the normal cells because they are still relatively hard or impermeable.

IPT, therefore, is able to take advantage of the powerful cytotoxic effects of standard chemotherapy without having to use high doses.

Because the dosing is low, side effects are minimized and the treatments can be given more frequently. This gives cancer cells less time to become resistant to the drugs and apoptosis occurs in a much shorter time frame. This is accomplished while sparing the other normal cells in the body from being equally exposed to these toxins; hence, there are very limited “side effects”.

One essential consequence is that the immune system is relatively spared from being damaged so that it can continue to defend the body from this cancer. This allows the immune system to protect the body from other cancers that may be “brewing” and it can also continue to defend against any other possible intrusions, such as micro-organisms (which cause infection and extraneous), chemical poisons, EMFs, radiation and internally derived poisons from accumulated waste.

Insulin Potentiation Therapy – IPT In Summary

It is easy to manipulate the immediate environment around the cancer cells by having a person not eat for about 6 to 12 hours prior to treatment. A small, calculated dose of insulin is administered and after about 20 to 40 minutes, most of the insulin receptors on the cancer cells are saturated, making them more permeable. Once this occurs, a small (5-10%) dose of the appropriate chemotherapeutic drug is administered and becomes preferentially taken up by the cancer cells.

Insulin is Nature’s ‘bow’ that allows us to aim straight into the “target” (cancer cells). Personalized cancer care.

The conventional method of chemotherapy delivery is like throwing a hand grenade at a fly on the wall. We prefer a more rational and direct method, like using a fly swatter, although in this case, we would probably shoot the fly out of the window rather than kill it.