EHC Buffalo: Kalpana Patel, MD

PBM Photobiomodulation

What is PBM Photobiomodulation?

Photobiomodulation (PBM) modulates human tissue in any organ by the use of red or near-infrared light. This is delivered to stimulate, regenerate, and protect tissue that has either been injured or is degenerating or else is at risk of dying. It helps to heal damaged or dying cells through the Rejuvenation of mitochondrion. It helps to rejuvenate any organ systems of the human body, which are highly essential for life, including the optimal functioning of the brain.

The brain suffers from many different disorders classified into three broad categories :

1. Traumatic events (stroke, traumatic brain injury, and global ischemia).

2. Degenerative diseases (dementia, Alzheimer’s, and Parkinson’s).

3. Psychiatric disorders (depression, anxiety, post-traumatic stress disorder).


There is some evidence that all these seemingly diverse conditions can be benefited by applying light to the head. The research has shown that PBM can be used for cognitive enhancement in normal healthy people. In this transcranial PBM (tPBM) application, near-infrared (NIR) light is often applied to the head with better penetration. It requires 30 minutes sessions.

Cytochrome C oxidase (CCO, also known as complex IV) is a specific structure in mitochondria that ACTS as a photon receptor and thus plays a great role in modulating the PBM effect. PBM prevents respiratory inhibition from stress. When a cell is exposed to stress, oxidative molecule nitric oxide (NO) is produced and inhibits 02 uptakes by mitochondrion. The light treatment rejuvenates the cells by isolating nitric oxide (NO) and reversing the shift of oxygen in cytochrome C oxidase. This triggers transcription factors that alter gene expression levels. The binding of nitric oxide (NO) to copper (or heme) centers in the mitochondrial cytochrome C oxidase (CCO) inhibits cell respiration. But cytochrome C oxidase, which absorbs red or near-infrared (NIR) light, dissociates nitric oxide, restoring oxygen, increasing cellular respiration, and forming adenosine triphosphate (ATP). This triggers a cascade of intracellular reactions involving nitric oxide, reactive oxygen species (ROS), and cyclic adenosine phosphate (cAMP) that produce beneficial effects of PBM.

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EHC Buffalo: Kalpana Patel, MD

EHC Buffalo: Kalpana Patel, MD

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CONTACT INFO:

Phone:

(716) 300-5505 

ADDRESS:

65 Wehrle Drive, Buffalo,
NY 14225 

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Insurance Information This is a specialty Clinic. We do not take any insurance. Our services are considered "Out of Network". It is your responsibility to contact your insurance company before committing to our program in order to determine the exact policies of your insurance plan. We will provide all of the billing information required by your insurer to get reimbursement if allowed. However, many treatments are considered off-label or not the usual standard of care. Thus there is no guarantee that your insurance company will reimburse you for any of our treatments. Please note that if you choose to submit our invoice to your insurance company, any or all services may be denied. We do not accept Medicare either. We have opted out of Medicare. You may check with your Medicare insurance what this means in your special case. We accept payments at the time of service, either check, cash, or credit card.