Nitro Redox Medicine- Medicine of future for chronic
degenerative disease prevention
Mitochondrial function, cellular signaling, cellular proliferation, differentiation and
apoptosis, immune-modulation, cancer growth, cardiac rhythm and circadian rhythm,
neuroplasticity, sympathetic tone, enzymatic function, receptor function, endothelial
function, gene expression and telomere length are all examples of Redox mediated
processes supported in peer reviewed literature.
Our body’s antioxidant defense mechanisms represent an active process fulfilled
by metabolic energy systems, antioxidant enzymes and epigenetics, in addition to the
roles of more well-known small molecule antioxidants and related detox compounds.
Reactive oxygen species (ROS) are necessary participants in normal biochemical
functions but can induce pathology when imbalanced. The endogenous production of
ROS during normal signaling is essential for cellular regeneration and healing effects.
However, excessive ROS production and accumulation leads to detrimental processes
that cause degeneration and cellular injury. Oxidative stress related disease occurs
when antioxidant defenses cannot balance the production of ROS.
Redox manipulation can improve homeostasis and cellular health, but it can also be
used as a clinical tool. We are just now seeing revolutionary new therapies being
developed from this concept.
The age-dependent Nitro-redox imbalance is closely related to oxidative stress and
the various syndromes associated with “aging”. ROS overproduction is involved in
diverse oxidative stress related diseases such as degenerative, autoimmune, metabolic,
chronic inflammatory, chronic infectious, and psychological diseases, plus cancers,
aging, pain and many more.
In order to develop effective therapeutic approaches against oxidative stress related
diseases, it is important to identify the mechanisms underlying the initial pathological
events. Targeted antioxidant treatments are a promising therapeutic approach.
However, the complex nature of oxidative stress related diseases and failure of
monotherapies suggest that an antioxidant therapy should be accompanied by
additional targeted therapeutic interventions to enhance the restoration of the Nitro-
redox balance. This is what we provide at EHC-BUFFALO